Pharmacotherapy : a pathophysiologic approach / editors, Joseph T. Dipiro ... [et al.].
Contributor(s): DiPiro, Joseph T.Material type: TextPublisher: New York : McGraw-Hill, c2005Edition: 6th ed.Description: xxxiii, 2802 p. : ill. (some col.) ; 27 cm.ISBN: 0071416137; 9780415334020; 0071416137; 0415334020 (alk. paper).Subject(s): Chemotherapy | Physiology, Pathological | Drug TherapyDDC classification: 615.8 Online resources: WorldCat details | Ebook Fulltext
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|615.7042 PHA 2005 Pharmacoepidemiology /||615.78 BRA 1996 Autonomic pharmacology /||615.8 PHA Pharmacotherapy :||615.8 PHA Pharmacotherapy :||615.854 RAN 2002 Nutraceuticals /||615.9 CAS 2003 Casarett and Doull's essentials of toxicology /||615.9 CAS 2010 Casarett & Doull's essentials of toxicology /|
Includes bibliographical references and index.
Table of contents Ch. 1. Enzyme structure and function / Edward A. Meighen --
Ch. 2. Mechanisms / Bruce A. Palfey --
Cytochrome P450 example / W. Edward Lindup and Neil R. Kitteringham --
Carbonic anhydrase example / Claudiu T. Supuran, Andrea Scozzafava and Angela Casini --
Proteases example / Andre J. Niestroj and Hans-Ulrich Demuth --
Ch. 3. Kinetics / Irene Lee and Anthony J. Berdis --
Ch. 4. Enzyme inhibitors / Jure Stojan --
Ch. 5. Development of enzyme inhibitors as drugs / H. John Smith and Claire Simons --
Enzyme inhibitor examples for the treatment of breast cancer / L. W. Lawrence Woo --
Enzyme inhibitor examples for the treatment of prostate tumor / Samer Haidar and Rolf W. Hartmann --
Thrombin inhibitor examples / Torsten Steinmetzer --
HIV-1 protease drug development examples / Paul J. Ala and Chong-Hwan Chang --
Metalloproteinase-collagenase inhibitor examples / Claudiu T. Supuran and Andrea Scozzafava.
"Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibition: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce the structure, substrates, kinetics, and mechanisms of enzymes. Subsequent chapters discuss the different types of enzyme inhibitors and the principles involved in developing them into effective drugs."--BOOK JACKET.