Pharmacotherapy : a pathophysiologic approach / editors, Joseph T. Dipiro ... [et al.].

Contributor(s): DiPiro, Joseph T Material type: Text

TextLanguage: English Publication details: New York : McGraw-Hill, c2005. Edition: 6th edDescription: xxxiii, 2802 p. : ill. (some col.) ; 27 cmISBN: 0071416137; 9780415334020; 0071416137; 0415334020 (alk. paper)Subject(s): Chemotherapy | Physiology, Pathological | Drug TherapyDDC classification: 615.8 LOC classification: RM263 | .P56 2005NLM classification: WB 330Online resources: WorldCat details | Ebook Fulltext

Contents:

TOC Ch. 1. Enzyme structure and function / Edward A. Meighen -- Ch. 2. Mechanisms / Bruce A. Palfey -- Cytochrome P450 example / W. Edward Lindup and Neil R. Kitteringham -- Carbonic anhydrase example / Claudiu T. Supuran, Andrea Scozzafava and Angela Casini -- Proteases example / Andre J. Niestroj and Hans-Ulrich Demuth -- Ch. 3. Kinetics / Irene Lee and Anthony J. Berdis -- Ch. 4. Enzyme inhibitors / Jure Stojan -- Ch. 5. Development of enzyme inhibitors as drugs / H. John Smith and Claire Simons -- Enzyme inhibitor examples for the treatment of breast cancer / L. W. Lawrence Woo -- Enzyme inhibitor examples for the treatment of prostate tumor / Samer Haidar and Rolf W. Hartmann -- Thrombin inhibitor examples / Torsten Steinmetzer -- HIV-1 protease drug development examples / Paul J. Ala and Chong-Hwan Chang -- Metalloproteinase-collagenase inhibitor examples / Claudiu T. Supuran and Andrea Scozzafava.

Summary: Summary: "Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibition: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce the structure, substrates, kinetics, and mechanisms of enzymes. Subsequent chapters discuss the different types of enzyme inhibitors and the principles involved in developing them into effective drugs."--BOOK JACKET.

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Holdings
Item type	Current library	Collection	Call number	Copy number	Status	Barcode
E-Book	Dr. S. R. Lasker Library, EWU E-book	Non-fiction	615.8 PHA 2005 (Browse shelf(Opens below))		Not for loan
Text	Dr. S. R. Lasker Library, EWU Reserve Section	Non-fiction	615.8 PHA (Browse shelf(Opens below))	C-1	Not For Loan	19818
Text	Dr. S. R. Lasker Library, EWU Reserve Section	Non-fiction	615.8 PHA (Browse shelf(Opens below))	C-2	Not For Loan	19819
Text	Dr. S. R. Lasker Library, EWU Circulation Section	Non-fiction	615.8 PHA (Browse shelf(Opens below))	C-3	Available	19820

Total holds: 0

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Previous	615.7 GII 2001 Introduction to drug metabolism /	615.7 ROC 1995 Clinical pharmacokinetics :	615.7042 PHA 2005 Pharmacoepidemiology /	615.8 PHA 2005 Pharmacotherapy :	615.9 CAS 2003 Casarett and Doull's essentials of toxicology /	615.9 CAS 2015 Casarett & Doull's essentials of toxicology /	615.9 LOE 1996 Essentials of toxicology /	Next

Includes bibliographical references and index.

TOC Ch. 1. Enzyme structure and function / Edward A. Meighen --
Ch. 2. Mechanisms / Bruce A. Palfey --
Cytochrome P450 example / W. Edward Lindup and Neil R. Kitteringham --
Carbonic anhydrase example / Claudiu T. Supuran, Andrea Scozzafava and Angela Casini --
Proteases example / Andre J. Niestroj and Hans-Ulrich Demuth --
Ch. 3. Kinetics / Irene Lee and Anthony J. Berdis --
Ch. 4. Enzyme inhibitors / Jure Stojan --
Ch. 5. Development of enzyme inhibitors as drugs / H. John Smith and Claire Simons --
Enzyme inhibitor examples for the treatment of breast cancer / L. W. Lawrence Woo --
Enzyme inhibitor examples for the treatment of prostate tumor / Samer Haidar and Rolf W. Hartmann --
Thrombin inhibitor examples / Torsten Steinmetzer --
HIV-1 protease drug development examples / Paul J. Ala and Chong-Hwan Chang --
Metalloproteinase-collagenase inhibitor examples / Claudiu T. Supuran and Andrea Scozzafava.

Summary:
"Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibition: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce the structure, substrates, kinetics, and mechanisms of enzymes. Subsequent chapters discuss the different types of enzyme inhibitors and the principles involved in developing them into effective drugs."--BOOK JACKET.

Pharmacy

Tahur Ahmed

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