000 05756cam a2200409 a 4500
001 6449
003 BD-DhEWU
005 20171212161218.0
008 081003s2009 enka g b 001 0 eng d
010 _a2008044502
020 _a9780470741689 (hbk.)
020 _a0470741686 (hbk.)
020 _a9780470741672 (pbk.)
020 _a0470741678 (pbk.)
035 _a(OCoLC)259265604
040 _aStDuBDS
041 _aeng
082 0 4 _a615.3
_bDEM 2009
100 _aDewick, Paul M.
245 1 0 _aMedicinal natural products :
_ba biosynthetic approach /
_cPaul M. Dewick.
250 _a3rd ed.
260 _aOxford :
300 _ax, 539 p. :
_bill. ;
_c26 cm.
504 _aIncludes bibliographical references and index.
505 _tTOC
_a1. ABOUT THIS BOOK, AND HOW TO USE IT. The Subject. The Aim. The Approach. The Topics. The Figures. Further Reading. What to Study. What to Learn. Nomenclature. Conventions Regarding Acids, Bases, and Ions. Some Common Abbreviations. Further Reading. 2. SECONDARY METABOLISM: THE BUILDING BLOCKS AND CONSTRUCTION MECHANISMS. Primary and Secondary Metabolism. The Building Blocks. The Construction Mechanisms. Alkylation Reactions: Nucleophilic Substitution. Dehydrogenases. Oxidases. Monooxygenases. Dioxygenases. Amine Oxidases. Baeyer-Villiger Monooxygenases. Some Vitamins Associated with the Construction Mechanisms. Elucidating Biosynthetic Pathways. Further Reading. 3. THE ACETATE PATHWAY: FATTY ACIDS AND POLYKETIDES. Fatty Acid Synthase: Saturated Fatty Acids. Unsaturated Fatty Acids. Uncommon Fatty Acids. Prostaglandins. Thromboxanes. Leukotrienes. Polyketide Synthases: Generalities. Polyketide Synthases: Macrolides. Macrolide Antibiotics, Erythromycins, Oleandomycin and Spiramycin, Tylosin, Avermectins, Polyene Antifungals, Tacrolimus and Sirolimus, Rifamycins. Polyketide Synthases: Linear Polyketides and Polyethers. Diels-Alder Cyclizations. Polyketide Synthases: Aromatics. Senna, Hypericum / St John?s Wort, Mycophenolic acid, Khellin and Cromoglicate, Griseofulvin. Poison Ivy and Poison Oak, Cannabis, Aflatoxins, Tetracyclines, Anthracycline Antibiotics. Further Reading. 4. THE SHIKIMATE PATHWAY: AROMATIC AMINO ACIDS AND PHENYLPROPANOIDS. Aromatic Amino Acids and Simple Benzoic Acids. Phenylpropanoids. Cinnamic Acids and Esters. Lignans and Lignin. Phenylpropenes. Benzoic Acids from C6C3 Compounds. Coumarins. Aromatic Polyketides. Styrylpyrones, Diarylheptanoids. Flavonoids and Stilbenes. Flavonolignans. Isoflavonoids. Terpenoid Quinones. Further Reading. 5. THE MEVALONATE AND METHYLERYTHRITOL PHOSPHATE PATHWAYS: TERPENOIDS AND STEROIDS. Mevalonic Acid and Methylerythritol Phosphate. Hemiterpenes. Monoterpenes. Irregular Monoterpenes. Iridoids. Sesquiterpenes. Artemisinin, Gossypol, Trichothecenes. Diterpenes. Sesterterpenes. Triterpenes. Steroids. Stereochemistry and Nomenclature. Cholesterol. Phytosterols. Vitamin D. Steroidal Saponins. Cardioactive Glycosides. Bile Acids. Adrenocortical Hormones/Corticosteroids. Semi-Synthesis of Corticosteroids. Progestogens. Oestrogens. Androgens. Tetraterpenes. Higher Terpenoids. Further Reading. 6. ALKALOIDS. Alkaloids Derived from Ornithine. Alkaloids Derived from Lysine. Alkaloids Derived from Nicotinic Acid. Alkaloids Derived from Tyrosine. Phenylethylamines and Simple Tetrahydroisoquinoline Alkaloids. Modified Benzyltetrahydroisoquinoline Alkaloids. Phenethylisoquinoline Alkaloids. Terpenoid Tetrahydroisoquinoline Alkaloids. Amaryllidaceae Alkaloids. Alkaloids Derived from Tryptophan. Simple Indole Alkaloids. Simple - Carboline Alkaloids. Terpenoid Indole Alkaloids. Quinoline Alkaloids. Pyrroloindole Alkaloids. Ergot Alkaloids. Alkaloids Derived from Anthranilic Acid. Alkaloids Derived From Histidine. Alkaloids Derived by Amination Reactions. Acetate-Derived Alkaloids. Phenylalanine-Derived Alkaloids. Terpenoid Alkaloids. Steroidal Alkaloids. Purine Alkaloids. Further Reading. 7. PEPTIDES, PROTEINS, AND OTHER AMINO ACID DERIVATIVES. Peptides and Proteins. Ribosomal Peptide Biosynthesis. Peptide Hormones. Thyroid Hormones. Hypothalamic Hormones. Hormone, Growth Hormone-releasing Hormone/Factor, Somatostatin. Anterior Pituitory Hormones. Posterior Pituitory Hormones. Pancreatic Hormones. Interferons. Opioid Peptides. Ribosomal Peptide Toxins. Death Cap (Amanita phalloides), Ricin, Botulinum Toxin, Conotoxins, Snake Venoms, Gila Monster Venom. Enzymes. Nonribosomal Peptide Biosynthesis. Bacitracins, Capreomycin, Polymyxins, Daptomycin, Cyclosporins, Vancomycin and Teicoplanin, Bleomycin, Streptogramins, Dactinomycin, Cycloserine. Modified Peptides: Penicillins, Cephalosporins and Other ?-Lactams. Cyanogenic Glycosides. Glucosinolates. Cysteine Sulphoxides. Further Reading. 8. CARBOHYDRATES. Monosaccharides. Oligosaccharides. Polysaccharides. Aminosugars and Aminoglycosides. Aminoglycoside Antibiotics, Streptamine-containing Antibiotics, 2-Deoxystreptamine-containing Antibiotics, Acarbose, Lincomycin and Clindamycin. Further Reading. Index.
520 _a'Medicinal Natural Products' provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focusing on the metabolic sequences leading to various classes of natural products.
526 _aPharmacy
590 _aRokon Mahamud
650 0 _aNatural products.
650 0 _aBiosynthesis.
651 0 _aPharmacognosy.
856 4 2 _3WorldCat details
856 4 0 _3Ebook Fulltext
942 _2ddc
999 _c6449
999 _c6449
999 _c6449